SleepIsLost
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Hi, I'm Peter, also known at reddit and nofap.com as SleepIsLost.
Gary Wilson might be wrong about the whole D2 receptor downregulation/desensitization as well. So he could also be wrong about the "permanent" damage.
In 2017 I participated in a porn addiction study at University Medical Center Groningen in The Netherlands to investigate if porn addiction down-regulates D2 receptors in the nucleus accumbens by using radioactive raclopride (selective dopamine D2 antagonist) in a PET scan and an fMRI scan to scan the reward pathway VTA - NAcc - PFC.
Guess what, today I called the with the doctor to ask him the results, because I was losing patience, and wanted to know the results, which is: there was no D2 receptor down-regulation in any of the addicted participants, including me. They all had issues with low motivation, anhedonia, anxiety and severe PAWS, otherwise known as prolonged withdrawal. (including me). My brain showed normal D2 binding and normal blood flow to the prefrontal cortex. No sign of hypofrontility. The MRI also showed no sign of abnormalities in the nucleus accumbens of all participants.
We talked about other dopaminergic receptors that could be involved and maybe D3 has something to do with our problems.
The study is about to be published on pubmed, but it can take some time.
About myself: I have relapsed multiple times and no real bad withdrawal symptoms have come back. I still believe PAWS (withdrawal) from this addiction is real and it's a dopaminergic problem, but D2 receptors are not involved according to this study. My brain showed normal D2 density just as the controls. There are other systems involved, and me and the guy who performed the study hypothesize opioid and dopamine anomalies in the VTA (ventral tegmental area), but not with D2 receptors in the NAcc (nucleus accumbens)
I was kind of disappointed and also a bit sceptical, because I was hoping to see some changes in my brain. To prove that this porn addiction really is a thing and can be measured with scans. It's strange that people with other behavior addictions like gambling, do show this blunted D2 binding... This study can be used as fuel by the porn addiction naysayers. So I hope this study gets peer reviewed and more faculties perform more and advanced studies on the matter
Hi, I'm Peter, also known at reddit and nofap.com as SleepIsLost.
Gary Wilson might be wrong about the whole D2 receptor downregulation/desensitization as well. So he could also be wrong about the "permanent" damage.
In 2017 I participated in a porn addiction study at University Medical Center Groningen in The Netherlands to investigate if porn addiction down-regulates D2 receptors in the nucleus accumbens by using radioactive raclopride (selective dopamine D2 antagonist) in a PET scan and an fMRI scan to scan the reward pathway VTA - NAcc - PFC.
.
Guess what, today I called the with the doctor to ask him the results, because I was losing patience, and wanted to know the results, which is: there was no D2 receptor down-regulation in any of the addicted participants, including me. They all had issues with low motivation, anhedonia, anxiety and severe PAWS, otherwise known as prolonged withdrawal. (including me). My brain showed normal D2 binding and normal blood flow to the prefrontal cortex. No sign of hypofrontility. The MRI also showed no sign of abnormalities in the nucleus accumbens of all participants.
We talked about other dopaminergic receptors that could be involved and maybe D3 has something to do with our problems.
The study is about to be published on pubmed, but it can take some time.
About myself: I have relapsed multiple times and no real bad withdrawal symptoms have come back. I still believe PAWS (withdrawal) from this addiction is real and it's a dopaminergic problem, but D2 receptors are not involved according to this study. My brain showed normal D2 density just as the controls. There are other systems involved, and me and the guy who performed the study hypothesize opioid and dopamine anomalies in the VTA (ventral tegmental area), but not with D2 receptors in the NAcc (nucleus accumbens)
I was kind of disappointed and also a bit sceptical, because I was hoping to see some changes in my brain. To prove that this porn addiction really is a thing and can be measured with scans. It's strange that people with other behavior addictions like gambling, do show this blunted D2 binding... This study can be used as fuel by the porn addiction naysayers. So I hope this study gets peer reviewed and more faculties perform more and advanced studies on the matter